Analysis and Modulation of PACT, DICER and MBNL1 in the Context of Myotonic Dystrophy Type I

Analysis and Modulation of PACT, DICER and MBNL1 in the Context of Myotonic Dystrophy Type I

Myotonic Dystrophy Type I (DM1) is a multi-systemic genetic neuromuscular degenerative disease, has a prevalence in most populations of about 1:8000 and is caused by the nuclear retention of pathogenically expanded DMPK mRNA. A previous DM1 RNAi-kinome screen in our lab has identified kinases that r...

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Bibliographic Details
Main Author: Azimi, Mehrdad
Other Authors: Mackenzie, Alexander
Language:en
Published: Université d'Ottawa / University of Ottawa 2016
Subjects:
Myotonic Dystrophy Type I
DM1
PACT
DICER
TRBP
miRNA
PKR
Alternative splicing
Nuclear foci
MBNL1
DMPK
SERCA1
Insulin receptor
RISC
Online Access:http://hdl.handle.net/10393/35310
http://dx.doi.org/10.20381/ruor-268

Internet

http://hdl.handle.net/10393/35310
http://dx.doi.org/10.20381/ruor-268

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