Engineering Novel TNFα-armed Oncolytic Viruses for Combination Immunotherapy with SMAC Mimetics
Small molecular Inhibitor of Apoptosis (IAP) antagonists, known as Smac mimetic compounds (SMCs), are a novel class of anti-cancer drugs currently undergoing clinical trials. SMCs were designed to mimic the function of the pro-apoptotic protein, Smac, which directly depletes cells of cIAP1 and cIAP2...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2016
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| Online Access: | http://hdl.handle.net/10393/35513 http://dx.doi.org/10.20381/ruor-471 |