The Role of the M4 α-Helix in Lipid Sensing by a Pentameric Ligand-Gated Ion Channel

The Role of the M4 α-Helix in Lipid Sensing by a Pentameric Ligand-Gated Ion Channel

Pentameric ligand-gated ion channels (pLGICs) are membrane-embedded receptors found extensively in pre- and post-synaptic membranes throughout the nervous system where they play an important role in neurotransmission. The function of the prototypic pLGIC, the nicotinic acetylcholine receptor (nAChR)...

Full description

Bibliographic Details
Main Author: Hénault, Camille
Other Authors: Baenziger, John Edward
Format: Others
Language:en
Published: Université d'Ottawa / University of Ottawa 2021
Subjects:
Protein structure-function
Pentameric ligand-gated ion channel
Membrane protein
Lipid modulation
Nicotinic acetylcholine receptor
Electrophysiology
Two-electrode voltage clamp
Lipid-protein interaction
Online Access:http://hdl.handle.net/10393/42519
http://dx.doi.org/10.20381/ruor-26739

Internet

http://hdl.handle.net/10393/42519
http://dx.doi.org/10.20381/ruor-26739

Similar Items