Synthesis of fluorine-18-labeled losartan analogs as novel positron emission tomography tracers for cancer imaging

Synthesis of fluorine-18-labeled losartan analogs as novel positron emission tomography tracers for cancer imaging

Losartan is a selective antagonist of the angiotensin II type 1 receptor (AT1R). Several reports have highlighted the AT1R expression in several cancers enhancing tumor development and cancer progression. The aim of this thesis is the synthesis and evaluation of [18F]fluoroethyl-losartan ([18F]FEtLo...

Full description

Bibliographic Details
Main Author: Pijeira, Martha Sahylí Ortega
Other Authors: Bernardes, Emerson Soares
Format: Others
Language:en
Published: Biblioteca Digitais de Teses e Dissertações da USP 2019
Subjects:
avaliação biológica
biological evaluation
imagem PET de tumores AT1R-positivos
PET imaging of AT1R-positive tumors
síntese
synthesis
[19/18F]ammoniomethyltrifluoroborate-losartan
[19/18F]amoniometiltrifluoroborato-losartan
[19/18F]fluoroethyl-losartan
[19/18F]fluoroetil-losartan
Online Access:http://www.teses.usp.br/teses/disponiveis/85/85131/tde-10062019-095737/

Internet

http://www.teses.usp.br/teses/disponiveis/85/85131/tde-10062019-095737/

Similar Items