Purification of human recombinant Naglu from Sf9 cells and uptake studies with MPS IIIB fibroblasts

Purification of human recombinant Naglu from Sf9 cells and uptake studies with MPS IIIB fibroblasts

Mucopolysaccharidosis IIIB (MPS IIIB) is a rare, metabolic disorder that results from a deficiency in the lysosomal hydrolase, α-N-acetylglucosaminidase (Naglu). Naglu is a housekeeping enzyme involved in the degradation pathway of heparan sulfate. A deficiency in active Naglu leads to an accumulati...

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Bibliographic Details
Main Author: Ashmead, Rhea
Other Authors: Choy, Francis Y. M.
Format: Others
Language:English
en
Published: 2019
Subjects:
Mucopolysaccharidosis
Mucopolysaccharidosis IIIB
MPS IIIB
α-N-acetylglucosaminidase
Spodoptera frugiperda
Naglu
blood-brain barrier
Protein transduction domains
enzyme replacement therapy
lysosomal disorders
lysosomal storage disorders
protein purification
cell-penetrating peptides
Online Access:http://hdl.handle.net/1828/10958

Internet

http://hdl.handle.net/1828/10958

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