Droplet interface bilayers: microfluidic methods to model pharmacokinetics in artificial cell membranes

Droplet interface bilayers: microfluidic methods to model pharmacokinetics in artificial cell membranes

Modern drug development is an astronomically expensive and time consuming undertaking. Because of this, studying the pharmacokinetic properties of drugs in vitro has become an integral step early in the process of drug development, with the goal of preventing costly failures late in the process, and...

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Bibliographic Details
Main Author: Stephenson, Elanna
Other Authors: Elvira, Katherine S.
Format: Others
Language:English
en
Published: 2021
Subjects:
Microfluidics
Pharmacokinetics
Droplet Interface Bilayers
Phospholipids
Computational fluid dynamics
Surface chemistry
Artificial bilayers
Mechanical engineering
Chemoresistance
Online Access:http://hdl.handle.net/1828/13401
Korner, J. L.; Stephenson, E. B.; Elvira, K. S. A Bespoke Microfluidic Pharmacokinetic Compartment Model for Drug Absorption Using Artificial Cell Membranes. Lab Chip 2020, 20 (11), 1898–1906. https://doi.org/10.1039/D0LC00263A
Stephenson, E. B.; Elvira, K. S. Biomimetic Artificial Cells to Model the Effect of Membrane Asymmetry on Chemoresistance. Chem. Commun. 2021, 57 (53), 6534–6537. https://doi.org/10.1039/D1CC02043A

Internet

http://hdl.handle.net/1828/13401
Korner, J. L.; Stephenson, E. B.; Elvira, K. S. A Bespoke Microfluidic Pharmacokinetic Compartment Model for Drug Absorption Using Artificial Cell Membranes. Lab Chip 2020, 20 (11), 1898–1906. https://doi.org/10.1039/D0LC00263A
Stephenson, E. B.; Elvira, K. S. Biomimetic Artificial Cells to Model the Effect of Membrane Asymmetry on Chemoresistance. Chem. Commun. 2021, 57 (53), 6534–6537. https://doi.org/10.1039/D1CC02043A

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