Cytotoxic methylthioadenosine analogues
The gene for methylthioadenosine phosphorylase (MTAP) is absent in almost 30% of cancers, opening a door for selective chemotherapy. One strategy to target the absence of MTAP involves the design of a cytotoxic methylthioadenosine (MTA) analogue. Non-cancerous cells would break down the cytotoxic an...
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| Language: | English en |
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2016
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| Online Access: | http://hdl.handle.net/1828/7534 |