Structure of prion β-oligomers as determined by structural proteomics

Structure of prion β-oligomers as determined by structural proteomics

The conversion of the native monomeric cellular prion protein (PrPC) into an aggregated pathological β-oligomeric (PrPβ) and an infectious form (PrPSc) is the central element in the development of prion diseases. The structure of the aggregates and the molecular mechanisms of the conformational cha...

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Bibliographic Details
Main Author: Serpa, Jason John
Other Authors: Borchers, Christoph H.
Format: Others
Language:English
en
Published: 2017
Subjects:
β-oligomer
prion
PrP
HDX
hydrogen/deuterium exchange
crosslinking
mass spectrometry
limited proteolysis
surface modification
protein structure
proteomics
structural proteomics
prion structure
discrete molecular dynamics
CL-DMD
misfolding
aggregation
Online Access:https://dspace.library.uvic.ca//handle/1828/8548

Internet

https://dspace.library.uvic.ca//handle/1828/8548

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