Structure of prion β-oligomers as determined by structural proteomics
The conversion of the native monomeric cellular prion protein (PrPC) into an aggregated pathological β-oligomeric (PrPβ) and an infectious form (PrPSc) is the central element in the development of prion diseases. The structure of the aggregates and the molecular mechanisms of the conformational cha...
Main Author: | Serpa, Jason John |
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Other Authors: | Borchers, Christoph H. |
Format: | Others |
Language: | English en |
Published: |
2017
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Subjects: | |
Online Access: | https://dspace.library.uvic.ca//handle/1828/8548 |
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