Voltage Sensing Mechanism in the Voltage-gated and Proton (H+)-selective Ion Channel Hv1

Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlled by changes in membrane potential and the transmembrane pH gradient (ΔpH). The mechanism by which changes in ΔpH affect the apparent voltage dependence of GAQ activation is not understood. In order t...

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Bibliographic Details
Main Author: Randolph, Aaron L.
Format: Others
Published: VCU Scholars Compass 2014
Subjects:
Hv1
Online Access:http://scholarscompass.vcu.edu/etd/582
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1581&context=etd