Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
Recent studies have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor, sildenafil citrate, induces a powerful cardioprotective effect against ischemia-reperfusion (I/R) injury in rabbit and mouse hearts. However, the effect of this drug in inducing long-term protection against I/R injury...
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VCU Scholars Compass
2005
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| Online Access: | http://scholarscompass.vcu.edu/etd/727 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1726&context=etd |