Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
The goal of this study was to determine safety, tolerability and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on...
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| Format: | Others |
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VCU Scholars Compass
2005
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| Online Access: | http://scholarscompass.vcu.edu/etd/1381 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2380&context=etd |