Therapeutic drugs in cancer and resistance.
We investigated the mechanism of toxicity and resistance development of small molecule tyrosine kinase inhibitor lapatinib in HCT 116 colon cancer cells. Lapatinib mediated cell death in HCT 116 cells was caspase independent and involved cytosolic release of apoptosis inducing factor. Treatment of H...
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| Format: | Others |
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VCU Scholars Compass
2009
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| Online Access: | http://scholarscompass.vcu.edu/etd/1717 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2716&context=etd |