KLF2 IS REQUIRED FOR NORMAL MOUSE CARDIOVASCULAR DEVELOPMENT

KLF2 IS REQUIRED FOR NORMAL MOUSE CARDIOVASCULAR DEVELOPMENT

Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixe...

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Bibliographic Details
Main Author: Chiplunkar, Aditi Raghunath
Format: Others
Published: VCU Scholars Compass 2013
Subjects:
KLF2
Heart development
Mouse embryo
EMT
AV cushion
KLF4
Vascular development
Medical Genetics
Medical Sciences
Medicine and Health Sciences
Online Access:http://scholarscompass.vcu.edu/etd/2951
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3950&context=etd

Internet

http://scholarscompass.vcu.edu/etd/2951
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3950&context=etd

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