TOLERANCE OF THYMINE GLYCOL AT THE BLUNT DNA DOUBLE STRAND BREAK FOR NONHOMOLOGUS END JOINING REPAIR AND INTERFERENCE BY BASE EXCISION REPAIR

Radiotherapy is the clinical application of the ionizing radiation to treat cancer. Ionizing radiation causes multiple modes of damage to the DNA damage such as SSBs, DSBs and modified bases such as thymine glycol. These lesions can exist as clusters in one or two helical turns of DNA. DNA double-s...

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Bibliographic Details
Main Author: Chalasani, Sri Lakshmi
Format: Others
Published: VCU Scholars Compass 2015
Subjects:
Online Access:http://scholarscompass.vcu.edu/etd/3921
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4961&context=etd