Investigation of Gain-of-Function Induced by Mutant p53
p53 is mutated in 50% of all human cancers, and up to 70% of lung cancer. Mutant p53 is usually expressed at elevated levels in cancer cells and has been correlated with a poor prognosis. Cancer cells that express mutant p53 show an increase in oncogenic phenotypes including an increase in growth...
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| Format: | Others |
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VCU Scholars Compass
2015
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| Online Access: | http://scholarscompass.vcu.edu/etd/3965 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5001&context=etd |