Depletion of the Chromatin Remodeler CHD4 Sensitizes AML Blasts to Genotoxic Agents and Reduces Tumor Formation
Chromodomain Helicase DNA-Binding Protein 4 (CHD4) is an ATPase that alters the phasing of nucleosomes on DNA and has recently been implicated in DNA double stranded break (DSB) repair. Here, we show that depletion of CHD4 in Acute Myeloid Leukemia (AML) blasts induces a global relaxation of chromat...
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VCU Scholars Compass
2015
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| Online Access: | http://scholarscompass.vcu.edu/etd/4005 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5042&context=etd |