Normalizing Tumor Vasculature Using Sepiapterin to Increase Radiosensitivity
Our studies examine the role of nitric oxide synthase (NOS) in tumor vasculature. NOS is “uncoupled” in tumor cells, resulting in peroxynitrite (ONOO-) formation in lieu of nitric oxide (NO). NO signaling is critical for vascular function, thus uncoupling of eNOS in endothelial cells may partly exp...
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| Format: | Others |
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VCU Scholars Compass
2015
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| Online Access: | http://scholarscompass.vcu.edu/etd/4060 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5081&context=etd |