A Systems Biology Approach to Detect eQTLs Associated with miRNA and mRNA Co-expression Networks in the Nucleus Accumbens of Chronic Alcoholic Patients

A Systems Biology Approach to Detect eQTLs Associated with miRNA and mRNA Co-expression Networks in the Nucleus Accumbens of Chronic Alcoholic Patients

Alcohol Dependence (AD) is a chronic substance use disorder with moderate heritability (60%). Linkage and genome-wide association studies (GWAS) have implicated a number of loci; however, the molecular mechanisms underlying AD are unclear. Advances in systems biology allow genome-wide expression dat...

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Bibliographic Details
Main Author: Mamdani, Mohammed
Format: Others
Published: VCU Scholars Compass 2014
Subjects:
psychiatric genetics
genomics
gene networks
alcoholism
alcohol dependence
WGCNA
Computational Biology
Genetics
Genomics
Mental Disorders
Systems Biology
Systems Neuroscience
Translational Medical Research
Online Access:http://scholarscompass.vcu.edu/etd/4313
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5116&context=etd

Internet

http://scholarscompass.vcu.edu/etd/4313
http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=5116&context=etd

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