Single-particle cryo-EM of the ryanodine receptor from skeletal muscle: reconstitution into nanodiscs and the conformational effects of magnesium.
The RyR1 acts as an intracellular calcium channel that allows passage of Ca2+ from the sarcoplasmic reticulum to the cytoplasm; this increase in cytosolic Ca2+ is required for excitation-contraction coupling. Certain mutations in RyR1 have been directly linked to malignant hyperthermia (MH) and cent...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
VCU Scholars Compass
2017
|
| Online Access: | http://scholarscompass.vcu.edu/etd/4998 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6083&context=etd |