RATIONAL DESIGN OF ALLOSTERIC MODULATORS OF HEMOGLOBIN AS DUAL ACTING ANTISICKLING AGENTS

Intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) remains the principal cause of the pathophysiology associated with sickle cell disease (SCD). Naturally occurring and synthetic allosteric effectors of hemoglobin (AEH) have been investigated as potential therapeutic agents for th...

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Bibliographic Details
Main Author: Pagare, Piyusha P
Format: Others
Published: VCU Scholars Compass 2018
Subjects:
Online Access:https://scholarscompass.vcu.edu/etd/5451
https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6540&context=etd