RATIONAL DESIGN OF ALLOSTERIC MODULATORS OF HEMOGLOBIN AS DUAL ACTING ANTISICKLING AGENTS
Intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) remains the principal cause of the pathophysiology associated with sickle cell disease (SCD). Naturally occurring and synthetic allosteric effectors of hemoglobin (AEH) have been investigated as potential therapeutic agents for th...
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VCU Scholars Compass
2018
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| Online Access: | https://scholarscompass.vcu.edu/etd/5451 https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6540&context=etd |