Modulation of electron transport by Metformin in cardiac protection: role of complex I
Modulation of mitochondrial complex I during reperfusion reduces cardiac injury. Complex I exists in two structural states: active (A) and deactive (D) with transition from A→D during ischemia. Reperfusion reactivates D→A with an increase in ROS production. Metformin preserves the D-Form. Our aim wa...
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VCU Scholars Compass
2018
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| Online Access: | https://scholarscompass.vcu.edu/etd/5554 https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6645&context=etd |