Electrostatic Networks and Mechanisms of ΔpH-Dependent Gating in the Human Voltage-Gated Proton Channel Hv1

Electrostatic Networks and Mechanisms of ΔpH-Dependent Gating in the Human Voltage-Gated Proton Channel Hv1

The structure of the voltage-gated proton (H+) channel Hv1 is homologous to the voltage sensor domain (VSD) of tetrameric voltage-gated Na+, K+ and Ca2+ channels (VGCs), but lacks a pore domain and instead forms a homodimer. Similar to other VSD proteins, Hv1 is gated by changes in membrane potentia...

Full description

Bibliographic Details
Main Author: Bennett, Ashley L
Format: Others
Published: VCU Scholars Compass 2019
Subjects:
Hv1
voltage sensor domain
pH-dependent gating
pKa
salt bridge
electrostatic interactions
Biochemistry
Biophysics
Cellular and Molecular Physiology
Structural Biology
Online Access:https://scholarscompass.vcu.edu/etd/6046
https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=7142&context=etd

Internet

https://scholarscompass.vcu.edu/etd/6046
https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=7142&context=etd

Similar Items