An Enzymology and Inhibition Study of a cAMP-Dependent Protein Kinase Linked to ACTH-Independent Cushing's Syndrome
Cyclic-AMP dependent protein kinase (PKA) is a key intracellular signal transduction kinase that is modulated by Gs- and Gi-coupled GPCRs. Under normal physiological conditions, PKA exists as an inactive holoenzyme made up of two catalytic subunits and two regulatory subunits. Upon cAMP binding to t...
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| Format: | Others |
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VCU Scholars Compass
2019
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| Online Access: | https://scholarscompass.vcu.edu/etd/6058 https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=7168&context=etd |