SRC INHIBITORS POTENTIATE UCN-01-INDUCED APOPTOSIS IN HUMAN MULTIPLE MYELOMA CELLS THROUGH A RAS/RAF/MEK/ERK-DEPENDENT MECHANISM
The goal of this study is to determine whether SKI-606, a Src/abl inhibitor, potentiates chk1 inhibitor UCN-01 to induce apoptosis in multiple myeloma cells, and what mechanism maybe involved. We found that the co-exposure of human myeloma cells (e.g., U266, RPMI8226, MM.1S and its dexamethasone-res...
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| Format: | Others |
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VCU Scholars Compass
2007
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| Online Access: | http://scholarscompass.vcu.edu/etd_retro/90 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1089&context=etd_retro |