SYNTHESIS AND BIOLOGICAL EVALUATION OF CCR5 ANTAGONISTS AS NOVEL ANTI-PROSTATE CANCER AGENTS
The chemokine receptor CCR5 has been implicated in the pathogenesis of prostate cancer (PCa). A novel series of piperazine derivatives have been designed and synthesized as CCR5 antagonists and their activity as inhibitors of PCa cell lines proliferation was explored. A lead compound has been iden...
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VCU Scholars Compass
2007
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| Online Access: | http://scholarscompass.vcu.edu/etd_retro/159 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1158&context=etd_retro |