Mechanism of PTEN binding to model membranes
PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a potent tumor suppressor. PTEN’s tumor suppressor action is rooted in its phosphatase function on the lipid substrate phosphatidylinositol-(3,4,5)-trisphosphate (PI(3,4,5)P3). PTEN’s enzymatic activity is specific for the...
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Digital WPI
2018
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| Online Access: | https://digitalcommons.wpi.edu/etd-dissertations/176 https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1175&context=etd-dissertations |