Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia

Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia

Chronic cerebral hypoperfusion-derived brain damage contributes to the progression of vascular cognitive impairment and dementia (VCID). Cumulative evidence has shown that microRNAs (miRs) are emerging as novel therapeutic targets for CNS disorders. In this study, it is sought to determine the regul...

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Bibliographic Details
Main Authors: Chen, Y. (Author), Foley, L. (Author), Hamblin, M.H (Author), Hitchens, T.K (Author), Huang, Y. (Author), Li, S. (Author), Sun, P. (Author), Xu, Y. (Author), Yin, K.-J (Author), Zhou, C. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
AKT3
Brain
Brain damage
Cognitive impairment
Genetic deficiencies
Gray matter
Gray matter lesion
grey matter lesions
IL-10ra
IL-10RA
Mammals
microRNAs
miR-15a/16-1
Mir-15a/16-1
Neurodegenerative diseases
RNA
vascular cognitive impairment and dementia
Vascular cognitive impairment and dementia
white matter lesions
White matter lesions
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