Protein sensors combining both on-and-off model for antibody homogeneous assay

Protein sensors combining both on-and-off model for antibody homogeneous assay

Protein sensors based on allosteric enzymes responding to target binding with rapid changes in enzymatic activity are potential tools for homogeneous assays. However, a high signal-to-noise ratio (S/N) is difficult to achieve in their construction. A high S/N is critical to discriminate signals from...

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Bibliographic Details
Main Authors: Cai, X.-F (Author), Chen, J. (Author), Cui, J. (Author), Deng, H.-J (Author), Gan, C.-Y (Author), Hu, J.-L (Author), Hu, X. (Author), Huang, A.-L (Author), Li, J. (Author), Long, Q.-X (Author), Shu, Z.-C (Author), Tang, N. (Author), Tu, Z. (Author), Wang, J.-L (Author), Wang, Y.-W (Author), Zhang, W.-L (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2022
Subjects:
Allosteric enzymes
Antibodies
Antibody test
Biosensor
Biosensors
Chemical detection
Diseases
Enzymes
Homogeneous assay
Homogeneous assays
Nanoluc
NanoLuc
Nano-switches
Performance
Protein sensor
Protein switch
Protein switches
Serum samples
Signal to noise ratio
Viruses
Working models
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