Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

To enhance bone regeneration, the use of bone morphogenetic protein (BMP)-2 is an attractive option. Unfortunately, the dose-dependent side effects prevent its widespread use. Therefore, a novel osteogenic agent using a different mechanism of action than BMP-2 is highly desirable. Previous reports d...

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Bibliographic Details
Main Authors: Bal, Z. (Author), Fujimori, T. (Author), Hirai, H. (Author), Kaito, T. (Author), Kanie, Y. (Author), Kodama, J. (Author), Makino, T. (Author), Nakagawa, S. (Author), Nishida, M. (Author), Okada, S. (Author), Sakai, Y. (Author), Sakamoto, K. (Author), Takenaka, S. (Author), Takeyama, K. (Author), Tateiwa, D. (Author), Ukon, Y. (Author), Yamamori, N. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
autogenous bone
Autogenous bone
autograft
Autograft
Bone
Bone formation
bone grafting
Bone grafting
Bone morphogenetic protein-2
Cell culture
E2 receptor 4 agonist
EP4 agonist
Grafting (chemical)
Human bones
Lipids
prostaglandin
Prostaglandin E2
Rats
spinal fusion
Spinal fusion
Stem cells
xenograft
Xenograft
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