NIR-Based Intelligent Sensing of Product Yield Stress for High-Value Bioresorbable Polymer Processing

NIR-Based Intelligent Sensing of Product Yield Stress for High-Value Bioresorbable Polymer Processing

PLA (polylactide) is a bioresorbable polymer used in implantable medical and drug delivery devices. Like other bioresorbable polymers, PLA needs to be processed carefully to avoid degradation. In this work we combine in-process temperature, pressure, and NIR spectroscopy measurements with multivaria...

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Bibliographic Details
Main Authors: Creedon, L. (Author), Donovan, J. (Author), Lyons, J.G (Author), McAfee, M. (Author), Mulrennan, K. (Author), Munir, N. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
bioresorbable polymer
Bioresorbable polymers
Chemometrices
chemometrics
Decision trees
Drug delivery
extrusion
Forecasting
Functional polymers
Infrared devices
Least squares approximations
Medical device industry
Near infrared spectroscopy
NIR spectroscopy
Partial least-squares
PLA
PLS
Poly lactide
Processing condition
Quality control
random forest
Random forests
Regression analysis
soft sensor
Soft sensors
support vector regression
Support vector regressions
Yield stress
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