Fine Particulate Matter Induces Childhood Asthma Attacks via Extracellular Vesicle-Packaged Let-7i-5p-Mediated Modulation of the MAPK Signaling Pathway

Fine particulate matter less than 2.5 µm in diameter (PM2.5) is a major risk factor for acute asthma attacks in children. However, the biological mechanism underlying this association remains unclear. In the present study, PM2.5-treated HBE cells-secreted extracellular vesicles (PM2.5-EVs) caused cy...

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Bibliographic Details
Main Authors:	Chu, H. (Author), Du, M. (Author), Gan, C. (Author), Gao, F. (Author), Liang, J. (Author), Mao, Z. (Author), Tian, M. (Author), Wang, M. (Author), Wei, C. (Author), Xue, R. (Author), Zhang, Z. (Author), Zheng, R. (Author), Zhu, Z. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2022
Subjects:	animal Animals asthma Asthma Bagg albino mouse Cell signaling Cells child Child Childhood asthma Cytology disease model Disease Models, Animal Diseases exosome Extracellular Extracellular vesicle Extracellular Vesicles female Female Fine particulate matter genetics human Humans Let-7i-5p Mammals MAP Kinase Signaling System MAPK signaling MAPK signaling pathway MAPK signalling metabolism Mice Mice, Inbred BALB C microRNA MicroRNAs mirnlet7 microRNA, human mouse Muscle Particles (particulate matter) particulate matter Particulate Matter PM 2.5 signal transduction Signal Transduction Signaling Signalling pathways Smooth muscle cells
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Fine Particulate Matter Induces Childhood Asthma Attacks via Extracellular Vesicle-Packaged Let-7i-5p-Mediated Modulation of the MAPK Signaling Pathway

Internet

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