Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Dysregulation of extracellular matrix (ECM) synthesis, organization, and mechanics are hallmark features of diseases like fibrosis and cancer. However, most in vitro models fail to recapitulate the three-dimensional (3D) multi-scale hierarchical architecture of collagen-rich tissues and as a result,...

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Bibliographic Details
Main Authors: Evans, E.B (Author), Hopkins, C.M (Author), Howes, A. (Author), Morgan, J.R (Author), Nakhla, M.N (Author), Wilks, B.T (Author), Williams, G. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
3D tissue engineering
Adhesives
Advanced science
Alignment
Cell culture
collagen
Collagen
Collagen synthesis
connective tissue
Connective tissues
Disease phenotypes
extracellular matrix
Extracellular matrix synthesis
fibroblast
fibrosis
Hierarchical architectures
Histology
Human fibroblast
In-vitro models
Mammals
mechanics
Mechanics
mechanophenotype
Multi-scales
Musculoskeletal system
Nonlinear optics
Scaffolds (biology)
TGF-β1
Tissue
Tissue models
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