Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury

Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury

Toll-like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a promising strategy to control the overwhelming inflammation in ALI, there still lacks effective TLR inhibitors for clinical uses to date. A unique class...

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Bibliographic Details
Main Authors: Fung, S.-Y (Author), Gao, W. (Author), Gong, J. (Author), Liu, X. (Author), Liu, Y. (Author), Ma, A. (Author), Ma, H. (Author), Saferali, A. (Author), Sun, L. (Author), Turvey, S.E (Author), Wang, R. (Author), Yang, H. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
acute lung injury
Acute lung injury
Acute Lung Injury
Advanced science
animal
Animals
Bioactive nanoparticles
Biological organs
C57BL mouse
Cell signaling
disease model
Disease Models, Animal
drug effect
Drug repurposing
female
Female
Gold nanoparticles
human
Humans
Lipopolysaccharides
Liposomes
Macrophages
male
Male
Mammals
metabolism
metal nanoparticle
Metal Nanoparticles
Mice
Mice, Inbred C57BL
mouse
nanomedicine
Nanomedicine
Omeprazole
Pathology
procedures
proton pump inhibitor
Proton Pump Inhibitors
Proton-pump inhibitors
Receptor signaling
Repurposing
Targeted drug delivery
toll like receptor
Toll-like receptors
Toll-Like Receptors
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