Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development

Current therapeutic development in amyotrophic lateral sclerosis (ALS) relies on individual randomized clinical trials to test a specific investigational product in a single patient population. This approach has intrinsic limitations, including cost, time, and lack of flexibility. Adaptive platform...

Full description

Bibliographic Details
Main Authors: Ajroud-Driss, S. (Author), Alameda, G. (Author), Amber Malcolm, N.P (Author), Andrews, J. (Author), Appel, S.H (Author), Arcila-Londono, X. (Author), Babu, S. (Author), Bailey, A. (Author), Bazan, T. (Author), Bedlack, R. (Author), Benatar, M. (Author), Benson, M. (Author), Berry, J. (Author), Berry, J.D (Author), Bertorini, T. (Author), Bhuvaneswaran, K. (Author), Bind, M.A (Author), Biostatisticians (Author), Bocchio, S. (Author), Bolger, P. (Author), Bowser, R. (Author), Brown, R.H., Jr (Author), Bulat, A. (Author), Burford, M. (Author), Caress, J. (Author), Cartwright, M. (Author), Chan, J. (Author), Changkuon, G. (Author), Chase, M. (Author), Chen, I.-H.A (Author), Chibnik, L. (Author), Chibnik, L.B (Author), Clawson, L. (Author), Clinical Operations Team (Author), Cohen, J.A (Author), Connolly, M. (Author), Cudkowicz, M. (Author), Cudkowicz, M.E (Author), Dagostino, D. (Author), Davis, M. (Author), De Santiago, D. (Author), Deboo, A. (Author), Detry, M.A (Author), Diaz, F. (Author), DiMarzio, M. (Author), DiOrio, N. (Author), DiStefano, S. (Author), Donofrio, P.D (Author), Drake, K. (Author), Elliott, M. (Author), Elman, L. (Author), Eydinov, M. (Author), Farias, J. (Author), Faulconer, K. (Author), Fee, D. (Author), Feldman, E.L (Author), Felice, K. (Author), Fernandes, J.A.M (Author), Fetouh, A. (Author), Feulner, J. (Author), Figueroa-Szostek, P. (Author), for the Healey ALS Platform Trial Study Group (Author), Foster, L. (Author), Fournier, C. (Author), Garozzo, T. (Author), Ghasemi, M. (Author), Gladden, C. (Author), Glass, J. (Author), Gomes, J. (Author), Goutman, S.A (Author), Govindarajan, R. (Author), Goyal, N.A (Author), Grabert, S. (Author), Granit, V. (Author), Greene, E. (Author), Grogan, J. (Author), Hall, M. (Author), Hamilton, J. (Author), Harkey, B. (Author), Hayat, G. (Author), HEALEY ALS Platform Trial Study Group (Author), Heiman-Patterson, T. (Author), Heitzman, D. (Author), Henrique, J. (Author), Ilieva, H. (Author), Investigators (Author), Jabari, D. (Author), Jackson, C. (Author), Jacobsen, B. (Author), Jawdat, O. (Author), Jenkins, L. (Author), Jentoft, K. (Author), Jin, P. (Author), Johnson, K. (Author), Jones, V. (Author), Judith Guarnieri, N.P (Author), Julia Yasek, N.P (Author), Kamp, C. (Author), Kasarskis, E.J (Author), Katsovskiy, I. (Author), Katz, J. (Author), Kennedy, E. (Author), Kennedy, J. (Author), Kharakozova, O. (Author), Kittle, G. (Author), Kolb, S. (Author), Korin, A. (Author), Ladha, S. (Author), Lavery, C. (Author), Lewis, R. (Author), Li, X. (Author), Liao, B. (Author), Lim, S. (Author), Locatelli, E. (Author), Macklin, E. (Author), Maiser, S. (Author), Mamarabadi, M. (Author), Maragakis, N.J (Author), Martinez-Thompson, J. (Author), Mattos, A.D (Author), McCaffrey, A. (Author), McGarry, A. (Author), McIlduff, C. (Author), Medical Monitors (Author), Miller, T. (Author), Mosmiller, B. (Author), Nance, C. (Author), Nasri, M.A (Author), Nathan (Author), Newman, D.S (Author), Nicholson, K. (Author), Novak, I. (Author), Olney, N. (Author), Oskarsson, B. (Author), Ostrow, J. (Author), Owegi, M.A (Author), Paganoni, S. (Author), Pasinelli, P. (Author), Pattee, G.L (Author), Patterson, J. (Author), Peltier, A.C (Author), Piccione, E. (Author), Pothier, L. (Author), Quick, A. (Author), Quinn, C. (Author), Quintana, M. (Author), Rad, N. (Author), Randall, R. (Author), Rezania, K. (Author), Riley, K. (Author), Rosenfeld, J. (Author), Russell, J.W (Author), Rutkove, S. (Author), Sarah Heintzman, N.P (Author), Saville, B. (Author), Saville, B.R (Author), Scalia, J. (Author), Scott, R. (Author), Shah, J. (Author), Shaughnessy, A. (Author), Shefner, J. (Author), Sherman, A. (Author), Sherman, A.V (Author), Shroff, S. (Author), Simmons, Z. (Author), Sinani, E. (Author), Small, C. (Author), Statland, J. (Author), Steijlen, K. (Author), Stommel, E. (Author), Su, X. (Author), Suresh, N. (Author), Swenson, A. (Author), Tarasenko, N. (Author), Thaisetthawatkul, P. (Author), Thonhoff, J. (Author), Torti, M. (Author), Tourenne, C.L (Author), Tustison, E. (Author), Twydell, P. (Author), Uchil, A. (Author), Vakili, G.S (Author), Vestrucci, M. (Author), Vigneswaran, P. (Author), Vu, T. (Author), Wahab, Y. (Author), Walk, D. (Author), Weiss, M.D (Author), Whitaker, C. (Author), Whitworth, I. (Author), Wymer, J.P (Author), Young, E. (Author), Yu, H. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Online Access:View Fulltext in Publisher