Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project

Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project

The surrogate threshold effect (STE) is defined as the minimum treatment effect on a surrogate that is reliably predictive of a treatment effect on the clinical outcome. It provides a framework for implementing a clinical trial with a surrogate endpoint. The aim of this study was to update our previ...

Full description

Bibliographic Details
Main Authors: Bauer, D.C (Author), Black, D.M (Author), Bouxsein, M. (Author), Cauley, J.A (Author), Chines, A. (Author), Eastell, R. (Author), Khosla, S. (Author), Lui, L.-Y (Author), McCulloch, C.E (Author), Mitlak, B. (Author), Pavo, I. (Author), Vittinghoff, E. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
abaloparatide
alendronic acid
Article
arzoxifene
bazedoxifene
biological marker
Biomarkers
bisphosphonic acid derivative
bone density
Bone Density
bone density conservation agent
Bone Density Conservation Agents
calcitonin
clinical outcome
clodronic acid
Cochrane Library
denosumab
Diphosphonates
disease marker
Embase
etidronic acid
female
fracture
Fractures, Bone
hip fracture
human
Humans
ibandronic acid
lasofoxifene
Medline
morphometry
musculoskeletal system parameters
nonvertebral fracture
odanacatib
parathyroid hormone[1-34]
quantitative analysis
raloxifene
risedronic acid
risk reduction
romosozumab
selective estrogen receptor modulator
sodium fluoride
spine fracture
surrogate threshold effect
systematic review
tiludronic acid
validation study
zoledronic acid
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items