Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain

Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human-induced pluripotent stem cell-derived neural cell types (exc...

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Bibliographic Details
Main Authors: Aslebagh, R. (Author), Blurton-Jones, M. (Author), Gygi, S.P (Author), Hu, J. (Author), Ikezu, T. (Author), Jedrychowski, M.P (Author), McQuade, A.K (Author), Muraoka, S. (Author), Poon, W.W (Author), Shaffer, S.A (Author), You, Y. (Author), Young-Pearse, T. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Alzheimer disease
Alzheimer Disease
amyloid beta protein
Amyloid beta-Peptides
annexin
Article
astrocyte
Astrocytes
beta1 integrin
biological marker
Biomarkers
brain
Brain
brain tissue
cell differentiation
cell isolation
cognitive defect
Cognitive Dysfunction
controlled study
cytology
disease exacerbation
exosome
Extracellular Vesicles
gene ontology
human
human cell
human tissue
Humans
immunocytochemistry
induced pluripotent stem cell
Induced Pluripotent Stem Cells
integrin
Integrin beta1
Itgb1 protein, human
liquid chromatography-mass spectrometry
lysosome associated membrane protein 2
male
mass spectrometry
metabolism
microglia
mild cognitive impairment
nerve cell
oligodendroglia
pathology
pluripotent stem cell
protein ATP1A3
protein expression
protein FTH1
protein ITGA6
protein ITGAM
protein LCP1
protein LRP1
protein NCAM1
protein processing
proteome
Proteome
proteomics
tau protein
tau Proteins
transmission electron microscopy
unclassified drug
Western blotting
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