MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID-19 severe respiratory failure (MUST COVID): A retrospective cohort study

Background: Few therapies exist to treat severe COVID-19 respiratory failure once it develops. Given known diffuse pulmonary microthrombi on autopsy studies of COVID-19 patients, we hypothesized that tissue plasminogen activator (tPA) may improve pulmonary function in COVID-19 respiratory failure. M...

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Main Authors: Al-Shammaa, A. (Author), Anez-Bustillos, L. (Author), Baedorf-Kassis, E.N (Author), Banner-Goodspeed, V. (Author), Barrett, C.D (Author), Benjamin Christie, D., III (Author), Bull, T. (Author), Capers, K. (Author), Espinal, A. (Author), Guevara, A. (Author), Hajizadeh, N. (Author), Hattar, L. (Author), Hussain, S. (Author), Jhunjhunwala, R. (Author), McIntyre, R. (Author), Moore, E.E (Author), Moore, H.B (Author), Moore, P.K (Author), Moraco, A. (Author), Nemec, H. (Author), Nonnemacher, C. (Author), Orfanos, S. (Author), Rajcooar, N. (Author), Ramdeo, R. (Author), Sauaia, A. (Author), Shaefi, S. (Author), Talmor, D.S (Author), Thomas Buchanan, J. (Author), Wang, J. (Author), Wright, F.L (Author), Yacoub, M. (Author), Yaffe, M.B (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Online Access:View Fulltext in Publisher