Structural mechanism of TRPM7 channel regulation by intracellular magnesium

Structural mechanism of TRPM7 channel regulation by intracellular magnesium

Zn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic processes and signalling pathways. An emerging new paradigm is that the organismal balance of these cations predominantly depends on a common gatekeeper, the channel-kinase TRPM7. Despite extensive electrophysiological s...

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Bibliographic Details
Main Authors: Chubanov, V. (Author), Egawa, M. (Author), Gudermann, T. (Author), Kurnikova, M.G (Author), Leonhardt, M. (Author), Narangoda, C. (Author), Nörenberg, W. (Author), Rössig, A. (Author), Schaefer, M. (Author), Schmidt, E. (Author), Zierler, S. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
ATP
Magnesium
Molecular dynamics simulations
PIP2
TRP channels
TRPM7
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