Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation

Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation

Saponin-based adjuvants (SBAs) are promising new adjuvants that stand out as they not only enforce CD4 + T cell-mediated immunity and antibody responses, but also induce an unprecedented level of antigen cross-presentation by dendritic cells (DC) and subsequent CD8 + T cell activation. We discovered...

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Bibliographic Details
Main Authors: Adema, G.J (Author), den Brok, M.H (Author), Ho, N.I (Author), Huis in ’t Veld, L.G.M (Author), Wassink, M. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
Adjuvant
animal
Animals
antigen presentation
Antigen Presentation
C57BL mouse
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
cross presentation
Cross-presentation
Cross-Priming
dendritic cell
Dendritic cell
Dendritic Cells
endoplasmic reticulum
Endoplasmic Reticulum
ISCOM
metabolism
Mice
Mice, Inbred C57BL
mouse
saponin
Saponin
Saponins
Vaccine
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