Genome-wide association study and functional validation implicates JADE1 in tauopathy

Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amy...

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Main Authors: Andrews, S.J (Author), Attems, J. (Author), Ayalon, G. (Author), Beach, T.G (Author), Bhangale, T. (Author), Borukov, V.Y (Author), Bowles, K.R (Author), Cairns, N.J (Author), Casella, A. (Author), Cherry, J.D (Author), Cobos, I. (Author), Cohen, H.T (Author), Corrada, M.M (Author), Cortes, E.P (Author), Crary, J.F (Author), Dangoor, D.K (Author), de Paiva Lopes, K. (Author), Dickson, D.W (Author), Farrell, K. (Author), Fischer, P. (Author), Flanagan, M.E (Author), Franklin, E.E (Author), Frosch, M.P (Author), Frost, B. (Author), Fulton-Howard, B. (Author), Gandy, S. (Author), Gearing, M. (Author), Glass, J. (Author), Goate, A. (Author), Gonzalez, E.M (Author), Graham, R.R (Author), Han, N. (Author), Haroutunian, V. (Author), Hefti, M.M (Author), Hof, P.R (Author), Humphrey, J. (Author), Hunkapiller, J. (Author), Hyman, B.T (Author), Iida, M.A (Author), Kapoor, M. (Author), Kawas, C.H (Author), Keene, C.D (Author), Kim, S.H (Author), Kofler, J. (Author), Kovacs, G.G (Author), Latimer, C.S (Author), Lee, E.B (Author), Lutz, M.I (Author), Mao, Q. (Author), Marcora, E. (Author), McKee, A.C (Author), McMillan, C.T (Author), Mesulam, M.-M (Author), Metcalf, J. (Author), Montine, T.J (Author), Murray, M.E (Author), Nelson, P.T (Author), Novikova, G. (Author), Otero-Garcia, M. (Author), Perrin, R.J (Author), Pham, T. (Author), Poon, W. (Author), Purohit, D.P (Author), Raj, T. (Author), Renton, A.E (Author), Richardson, T.E (Author), Rissman, R.A (Author), Salehi, B. (Author), Sano, M. (Author), Schneider, J.A (Author), Shuldberg, S. (Author), Sissoko, C.T (Author), Stein, T.D (Author), Tang, W. (Author), Teich, A.F (Author), Trojanowski, J.Q (Author), Troncoso, J.C (Author), Udine, E. (Author), Vialle, R.A (Author), Vonsattel, J.-P (Author), Walker, J.M (Author), Walsh, H. (Author), Weintraub, S. (Author), White III, C.L (Author), Whitney, K. (Author), Wolk, D.A (Author), Woltjer, R.L (Author), Wong, G. (Author), Yu, L. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
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