Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been shown that familial PD-associated missense mutations...

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Bibliographic Details
Main Authors: Bartels, T. (Author), Cantlon, A. (Author), de Boni, L. (Author), Dettmer, U. (Author), Jaunmuktane, Z. (Author), Jiang, H. (Author), Kim, N. (Author), Lashley, T. (Author), Liu, L. (Author), Martin, E. (Author), Rovere, M. (Author), Sanderson, J. (Author), Sylvester, M. (Author), Wallis, A. (Author), Watson, A.H (Author), Zaccagnini, L. (Author), Zhelcheska, K. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
Aggregation
Aggregation transmission
DLB
Multimers
PD
α-Synuclein
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