Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been shown that familial PD-associated missense mutations...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media Deutschland GmbH
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |