Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been shown that familial PD-associated missense mutations...
Main Authors: | Bartels, T. (Author), Cantlon, A. (Author), de Boni, L. (Author), Dettmer, U. (Author), Jaunmuktane, Z. (Author), Jiang, H. (Author), Kim, N. (Author), Lashley, T. (Author), Liu, L. (Author), Martin, E. (Author), Rovere, M. (Author), Sanderson, J. (Author), Sylvester, M. (Author), Wallis, A. (Author), Watson, A.H (Author), Zaccagnini, L. (Author), Zhelcheska, K. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media Deutschland GmbH
2022
|
Subjects: | |
Online Access: | View Fulltext in Publisher |
Similar Items
-
In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
by: Maria Fouka, et al.
Published: (2020-09-01) -
Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
by: Hao Gu, et al.
Published: (2021-03-01) -
Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
by: Lijun Dai, et al.
Published: (2021-07-01) -
Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies
by: Takehiro Nakagaki, et al.
Published: (2021-09-01) -
Neurons and Glia Interplay in α-Synucleinopathies
by: Panagiota Mavroeidi, et al.
Published: (2021-05-01)