Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials

The objective of this analysis was to determine if there are sex differences with esketamine for treatment-resistant depression (TRD). Post hoc analyses of three randomized, controlled studies of esketamine in patients with TRD (TRANSFORM-1, TRANSFORM-2 [18–64 years], TRANSFORM-3 [≥ 65 years]) were...

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Bibliographic Details
Main Authors:	Canuso, C.M (Author), Cooper, K. (Author), Daly, E.J (Author), Freeman, M.P (Author), Jones, R.R (Author), Kornstein, S.G (Author), Nicholson, S. (Author)
Format:	Article
Language:	English
Published:	Springer 2022
Subjects:	adult Adult age aged analgesic agent antihypertensive agent antilipemic agent anxiety disorder Article attention disturbance benzodiazepine beta adrenergic receptor blocking agent cardiovascular disease Clinical Global Impression scale cohort analysis combination drug therapy controlled study depression Depression Depressive Disorder, Treatment-Resistant diabetes mellitus diagnosis time disease duration disease severity dissociative disorder dizziness double blind procedure Double-Blind Method drug efficacy drug hypersensitivity drug safety Drug Therapy, Combination drug withdrawal drunk sensation duloxetine dysgeusia elevated blood pressure escitalopram esketamine Esketamine extrasystole fatigue female Female functional status Generalized Anxiety Disorder-7 headache hip fracture hormonal therapy human Humans hypertension hypesthesia incidence ketamine Ketamine levothyroxine male Male mania Montgomery Asberg Depression Rating Scale motion sickness multicenter study (topic) multiple trauma Nasal Sprays nausea nose spray oral contraceptive agent panic paresthesia Patient Health Questionnaire 9 phase 3 clinical trial (topic) placebo post hoc analysis postmenopause premenopause prevalence proton pump inhibitor psychopharmacotherapy randomized controlled trial randomized controlled trial (topic) remission self report Self-rating Depression Scale sertraline Sex sex difference side effect single drug dose s-Ketamine somnolence systolic blood pressure tachycardia thyroid disease treatment outcome Treatment Outcome treatment resistant depression treatment response treatment withdrawal Treatment-resistant depression venlafaxine vertigo vomiting
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Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials

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