Overcoming constraints on the detection of recessive selection in human genes from population frequency data

Overcoming constraints on the detection of recessive selection in human genes from population frequency data

The identification of genes that evolve under recessive natural selection is a long-standing goal of population genetics research that has important applications to the discovery of genes associated with disease. We found that commonly used methods to evaluate selective constraint at the gene level...

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Bibliographic Details
Main Authors: Balick, D.J (Author), Do, R. (Author), Jordan, D.M (Author), Sunyaev, S. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
algorithm
Algorithms
allele
Alleles
biological model
constraint scores
dominant gene
gene frequency
Gene Frequency
Genes, Dominant
Genes, Recessive
genetic dominance
genetic predisposition
Genetic Predisposition to Disease
genetic selection
genetic variation
Genetic Variation
Genetics, Population
genomics
Genomics
genotype
Genotype
human
Humans
inference of selection
inheritance
Inheritance Patterns
Likelihood Functions
mode of inheritance
Models, Genetic
mutation
Mutation
population genetics
procedures
recessive gene
recessive human genes
recessive selection
Selection, Genetic
site frequency spectrum
statistical model
United Kingdom
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