Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

The health of the kidney filtration barrier requires communication among podocytes, endothelial cells, and mesangial cells. Disruption of these cell-cell interactions is thought to contribute to disease progression in chronic kidney diseases (CKDs). Podocyte ablation via doxycycline-inducible deleti...

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Bibliographic Details
Main Authors: Chen, F. (Author), Chen, H. (Author), Clark, A.R (Author), Greka, A. (Author), Marshall, J. (Author), Montesinos, M.S (Author), Nguyen, L. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
animal
animal cell
Animals
Article
cell communication
Cell Communication
cell damage
cell interaction
cell population
cell survival
chronic kidney failure
collagen type 4
controlled study
cytoskeleton
female
genetics
glomerulus filtration
integrin
knockout mouse
male
mesangium cell
metabolism
Mice
Mice, Knockout
mitochondrion
mouse
nonhuman
pathology
podocyte
Podocytes
protein expression
Renal Insufficiency, Chronic
RNA sequencing
signal transduction
single cell analysis
Single-Cell Analysis
transcriptome
Transcriptome
transcriptomics
upregulation
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