Antihistamines for cancer immunotherapy: More than just treating allergies
In this issue of Cancer Cell, Li et al. show that histamine released in allergic reactions and from tumor cells attenuates immunotherapy response. Histamine H1-receptor (H1R) signaling induces an M2-like phenotype in tumor-associated macrophages and increases VISTA expression, suppressing CD8+ T cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
NLM (Medline)
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |