SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization

SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization

The metabolic program is altered during macrophage activation and influences macrophage polarization. Glutaminolysis promotes accumulation of α-ketoglutarate (αKG), leading to Jumonji domain-containing protein D3 (Jmjd3)-dependent demethylation at H3K27me3 during M2 polarization of macrophages. Howe...

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Bibliographic Details
Main Authors: Cai, R. (Author), Cao, Y. (Author), Chen, Y. (Author), Cheng, J. (Author), Dong, B. (Author), Fan, Q. (Author), He, J. (Author), Hu, G. (Author), Ma, J. (Author), Tan, H. (Author), Tu, J. (Author), Wang, Q. (Author), Wang, T. (Author), Xue, W. (Author), Zheng, Q. (Author), Zhou, W. (Author), Zuo, Y. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
CP: Immunology
macrophage M2 polarization
SENP1
Sirt3
SUMOylation
α-ketoglutarate
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