A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived growth factor and a critical regulator of fetal organ development in mice and humans. Using a single-cell RNA sequencing (RNA-seq) atlas of salivary gland (SG) and a tamoxifen inducible Fgf10CreERT2:R26-tdTomato mouse, w...

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Bibliographic Details
Main Authors: Aure, M.H (Author), Basova, L. (Author), Bellusci, S. (Author), Delcroix, V. (Author), Hajihosseini, M.K (Author), Hoffman, M.P (Author), Makarenkova, H.P (Author), Mauduit, O. (Author), Mays, J.W (Author), Srivastava, A. (Author), Tucker, A.S (Author), Umazume, T. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
CFTR
CP: Developmental biology
duct cells
FGF10
FGFR2b signaling
Foxi1
ionocytes
niche cells
salivary gland
single-cell RNA sequencing
submandibular gland
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